Making the difference.
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T&T Scientific Corp.
SERVICES
- Formulation and Discovery
- Preclinical Development
- Clinical Trials Tech Transfer & GMP Manufacturing
- Commercial Manufacturing, Aseptic Fill and Finish
Get Your Proposal
TECHNOLOGIES
- NanoSizer FLOW Manufacturing
- NanoSizer Extrusion
- NanoSizer AUTO Technology
- NanoSizer Consumables
- Custom Nanoparticle Formulations
- ProFECT Formulation Technologies
The Future of Translational Nanomedicines:
CRO & CDMO with Pharmaceutical Drug Delivery
Formulations and Manufacturing: Technologies and Services
Lipid-Based Pharmaceutical Drug Products including Lipid Nanoparticles (LNP's), Liposomes, and Lipoplexes
Hybrid Lipid-Polymer Drugs, and Polymer-Based Delivery of API's such as mRNA & Proteins
Formulation and Manufacturing of Vaccines and Therapeutics
Speciality and Expertise on Delivery System for APIs:
mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides,
siRNA, DNA, Small and Large Molecules
Manufacturing Technologies
CDMO Manufacturing Services
Discovery and CRO Services
Formulation Technologies
T&T Scientific
T&T Scientific is a technology and service company focused on formulation and manufacturing of pharmaceutical nanomedicines. T&T Scientific has three main core departments: 1) Contract Research, Development and cGMP manufacturing. 2) Manufacturing Platform All-Inclusive Technologies for In-house or Sales. and 3) Lipid Nanoparticle Formulation Discovery, Optimizations, and Technologies. T&T Scientific has quality system managed by quality team and electronic quality system (Qualio). T&T Scientific quality department insures the quality of both drug products, and technology transfers to and from T&T Scientific. Moreover, the company has established a practical education platform. This platform connects the world in the field of nanomedicine therapeutics and vaccines for the most effective dissemination of information in the field.
T&T Scientific is a technology and service company focused on formulation and manufacturing of pharmaceutical nanomedicines. T&T Scientific has three main core departments: 1) Contract Research, Development and cGMP manufacturing. 2) Manufacturing Platform All-Inclusive Technologies for In-house or Sales. and 3) Lipid Nanoparticle Formulation Discovery, Optimizations, and Technologies. T&T Scientific has quality system managed by quality team and electronic quality system (Qualio). T&T Scientific quality department insures the quality of both drug products, and technology transfers to and from T&T Scientific. Moreover, the company has established a practical education platform. This platform connects the world in the field of nanomedicine therapeutics and vaccines for the most effective dissemination of information in the field.
T&T Scientific Corporation’s Quality Management System takes it guidance from 21 CFR Part 820 Quality System Regulations and complies all FDA GMP regulatory requirements. These requirements include 21 CFR Part 210, 21 CFR Part 211, and 21 CFR Part 11. The company claims no exclusions from the 21 CFR Part 820, 201, 211, 11 at 7140 Regal Lane, Knoxville, TN 37918.
Quality Policies at T&T Scientific are: 1) Foster a quality mindset that promotes a passion for continual improvement. 2) Ensure compliance with all applicable regulatory requirements. 3) Guarantee safe and effective products and services that fulfill customers needs.
T&T Scientific Quality
T&T Scientific is a full cGMP facility under one roof. T&T Scientific was founded to provide end users and customers with liposomal and lipid-nanoparticle equipment, research and development, and manufacturing services. And ultimately to help them achieve their goals in bringing life changing and life saving technologies to the world. Each department is a discrete functional unit of the organization, and a quality centric approach is at the core of all that we do. T&T’s Quality Operations are governed by the site’s Quality Manual. T&T Scientific Corporation’s Quality Management System takes it guidance from 21 CFR Part 820 Quality System Regulations and complies all FDA GMP regulatory requirements. These requirements include 21 CFR Part 210, 21 CFR Part 211, and 21 CFR Part 11. The company claims no exclusions from the 21 CFR Part 820, 201, 211, 11 at 7140 Regal Lane, Knoxville, TN 37918.
Services
T&T Scientific is a full cGMP operation under one umbrella. T&T operations unit covers projects from early discovery and optimization of drug products, delivery systems to pharmaceutical manufacturing process and analytical methods development, to clinical and commercial manufacturing. T&T is registered with the FDA and producing clinical materials for multiple pharmaceutical and bio technology companies. T&T Scientific comprehensive services are categorized to following:
Formulation and delivery system discovery and optimization
Analytical Methods, and Manufacturing Processes Development
Preclinical Pharmaceutical Development and Engineering Batch
Phase I, II Clinical Trial Manufacturing
Phase III Clinical Trial Batch Manufacturing
Commercial Batch Manufacturing
Sterile Filtration, Fill and Finish with Labeling for All of Above
Formulation and delivery system discovery and optimization Analytical Methods, and Manufacturing Processes Development Preclinical Pharmaceutical Development and Engineering Batch Phase I, II Clinical Trial Manufacturing Phase III Clinical Trial Batch Manufacturing Commercial Batch Manufacturing Sterile Filtration, Fill and Finish with Labeling for All of Above
T&T Scientific is constantly innovating in the space of nanomedicine manufacturing and formulations. T&T has expanded its manufacturing technology to highly scalable, precise, low cost, and small footprint solvent injection technologies, NanoSizer Flow, starting with patent-approved continuous extrusion technology. The solvent injection technology is being widely used in COVID vaccines and other gene therapy manufacturing applications. Moreover, the formulation department at T&T develops novel Lipid Nanoparticle (LNP) formulations for a wide variety of active pharmaceutical ingredients (APIs), including mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides, siRNA, DNA, Small and Large Molecules. ProFECT is the brand for T&T's lipid, polymer, and hybrid nanoparticle formulations.
Technologies
T&T Scientific is constantly innovating in the space of nanomedicine manufacturing and formulations. T&T has expanded its manufacturing technology to highly scalable, precise, low cost, and small footprint solvent injection technologies, NanoSizer Flow, starting with patent-approved continuous extrusion technology. The solvent injection technology is being widely used in COVID vaccines and other gene therapy manufacturing applications. Moreover, the formulation department at T&T develops novel Lipid Nanoparticle (LNP) formulations for a wide variety of active pharmaceutical ingredients (APIs), including mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides, siRNA, DNA, Small and Large Molecules. ProFECT is the brand for T&T's lipid, polymer, and hybrid nanoparticle formulations.
Unique experiences to drive engagement
T&T Scientific has introduced a low-cost, single-use liposome extrusion device that simplifies the process of preparing liposomes for research laboratories, manufacturing facilities, and clinical settings around the globe.
Unlike anything available to date, NanoSizerTM extruders ensure cleanliness and sterility while reducing the overall time of use from 45-60 minutes to 2 minutes. The low dead-volume design saves research dollars by reducing the amount of valuable biological material lost with conventional syringe filters.
Liposomes, polymerosomes, or related therapeutics can now be safely and effectively prepared in college science labs, academic research labs, pharmaceutical labs and production facilities labs, and even in hospitals and clinical settings.
NanoSizerTM extrusion technology from T&T brings confidence, convenience, and simplicity to doctors and scientists all around the world.
Products by T&T Scientific
50 nm NanoSizer MINI Liposome Extruder
100 nm NanoSizer MINI Liposome Extruder
50 Extrusion Syringes and 50 Low Dead-Volume Needles
Liposome Extrusion Holder/Heat Block
Complete NanoSizer Extrusion Kit (all pore sizes)
our team of seasoned experts has dedicated years to mastering Karl Fischer titration techniques. Whether you’re exploring its suitability for a specific application or encountering challenges with your samples, we’re here to help. Contact us today for free consultation and technical advice, tailored to your needs.
Our titrators are designed to deliver precise and reproducible results, backed by cutting-edge technology and expert craftsmanship. Every GR Scientific instrument comes with a standard two-year guarantee, ensuring peace of mind for your lab operations.
Maximize the performance and longevity of your equipment with an on-site visit from a GR Scientific engineer. This premium service includes:
Thorough Maintenance: Overhaul and clean the titration vessel and electrodes.
Precision Checks: Verify and adjust electronic settings using calibrated equipment.
Component Replacement: Replace reagents, molecular sieve, septa, 'O' rings, paper rolls, and printer ribbons.
Standard Verification: Conduct tests using known water content standards.
Calibration Certificate: Issue a new calibration certificate to ensure compliance and accuracy.
Hassle-Free Service: All travel costs and time on-site are included.
If your current titration machine is starting to show its age, it’s time to consider an upgrade. At GR Scientific, we understand the importance of staying ahead in your research or production processes. That’s why we offer innovative, state-of-the-art titration systems designed to replace outdated equipment with precision, speed, and user-friendly features that revolutionize your workflow.
Our latest models incorporate the most advanced technology available, including improved automation, enhanced sensitivity, and intuitive software interfaces. These innovations ensure more accurate results, reduced downtime, and seamless integration into modern lab environments.
Not sure which system is right for you? Our team of experts can guide you through the selection process, helping you choose the ideal machine to meet your specific requirements. Whether you’re looking for increased throughput, better accuracy, or compliance with the latest standards, we have a solution tailored to your needs.
By upgrading to a GR Scientific titration system, you’ll not only improve your operational efficiency but also future-proof your lab with cutting-edge technology. Don’t let your old equipment hold you back—embrace the potential of the future with GR Scientific.
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Grow with Us
- The Future of Translational Nanomedicines:
- CRO & CDMO with Pharmaceutical Drug Delivery
- Formulations and Manufacturing: Technologies and Services
- Lipid-Based Pharmaceutical Drug Products including Lipid Nanoparticles (LNP's), Liposomes, and Lipoplexes
- Hybrid Lipid-Polymer Drugs, and Polymer-Based Delivery of API's such as mRNA & Proteins
- Formulation and Manufacturing of Vaccines and Therapeutics
Speciality and Expertise on Delivery System for APIs:
- mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides,
- siRNA, DNA, Small and Large Molecules
- Manufacturing Technologies
- CDMO Manufacturing Services
- Discovery and CRO Services
- Formulation Technologies
T&T Scientific
T&T Scientific is a technology and service company focused on formulation and manufacturing of pharmaceutical nanomedicines. T&T Scientific has three main core departments: 1) Contract Research, Development and cGMP manufacturing. 2) Manufacturing Platform All-Inclusive Technologies for In-house or Sales. and 3) Lipid Nanoparticle Formulation Discovery, Optimizations, and Technologies. T&T Scientific has quality system managed by quality team and electronic quality system (Qualio). T&T Scientific quality department insures the quality of both drug products, and technology transfers to and from T&T Scientific. Moreover, the company has established a practical education platform. This platform connects the world in the field of nanomedicine therapeutics and vaccines for the most effective dissemination of information in the field.
T&T Scientific is a technology and service company focused on formulation and manufacturing of pharmaceutical nanomedicines. T&T Scientific has three main core departments: 1) Contract Research, Development and cGMP manufacturing. 2) Manufacturing Platform All-Inclusive Technologies for In-house or Sales. and 3) Lipid Nanoparticle Formulation Discovery, Optimizations, and Technologies. T&T Scientific has quality system managed by quality team and electronic quality system (Qualio). T&T Scientific quality department insures the quality of both drug products, and technology transfers to and from T&T Scientific. Moreover, the company has established a practical education platform. This platform connects the world in the field of nanomedicine therapeutics and vaccines for the most effective dissemination of information in the field.
T&T Scientific Corporation’s Quality Management System takes it guidance from 21 CFR Part 820 Quality System Regulations and complies all FDA GMP regulatory requirements. These requirements include 21 CFR Part 210, 21 CFR Part 211, and 21 CFR Part 11. The company claims no exclusions from the 21 CFR Part 820, 201, 211, 11 at 7140 Regal Lane, Knoxville, TN 37918.
Quality Policies at T&T Scientific are: 1) Foster a quality mindset that promotes a passion for continual improvement. 2) Ensure compliance with all applicable regulatory requirements. 3) Guarantee safe and effective products and services that fulfill customers needs.
T&T Scientific Quality
T&T Scientific is a full cGMP facility under one roof. T&T Scientific was founded to provide end users and customers with liposomal and lipid-nanoparticle equipment, research and development, and manufacturing services. And ultimately to help them achieve their goals in bringing life changing and life saving technologies to the world. Each department is a discrete functional unit of the organization, and a quality centric approach is at the core of all that we do. T&T’s Quality Operations are governed by the site’s Quality Manual. T&T Scientific Corporation’s Quality Management System takes it guidance from 21 CFR Part 820 Quality System Regulations and complies all FDA GMP regulatory requirements. These requirements include 21 CFR Part 210, 21 CFR Part 211, and 21 CFR Part 11. The company claims no exclusions from the 21 CFR Part 820, 201, 211, 11 at 7140 Regal Lane, Knoxville, TN 37918.
Services
T&T Scientific is a full cGMP operation under one umbrella. T&T operations unit covers projects from early discovery and optimization of drug products, delivery systems to pharmaceutical manufacturing process and analytical methods development, to clinical and commercial manufacturing. T&T is registered with the FDA and producing clinical materials for multiple pharmaceutical and bio technology companies. T&T Scientific comprehensive services are categorized to following:
Formulation and delivery system discovery and optimization
Analytical Methods, and Manufacturing Processes Development
Preclinical Pharmaceutical Development and Engineering Batch
Phase I, II Clinical Trial Manufacturing
Phase III Clinical Trial Batch Manufacturing
Commercial Batch Manufacturing
Sterile Filtration, Fill and Finish with Labeling for All of Above
Formulation and delivery system discovery and optimization Analytical Methods, and Manufacturing Processes Development Preclinical Pharmaceutical Development and Engineering Batch Phase I, II Clinical Trial Manufacturing Phase III Clinical Trial Batch Manufacturing Commercial Batch Manufacturing Sterile Filtration, Fill and Finish with Labeling for All of Above
T&T Scientific is constantly innovating in the space of nanomedicine manufacturing and formulations. T&T has expanded its manufacturing technology to highly scalable, precise, low cost, and small footprint solvent injection technologies, NanoSizer Flow, starting with patent-approved continuous extrusion technology. The solvent injection technology is being widely used in COVID vaccines and other gene therapy manufacturing applications. Moreover, the formulation department at T&T develops novel Lipid Nanoparticle (LNP) formulations for a wide variety of active pharmaceutical ingredients (APIs), including mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides, siRNA, DNA, Small and Large Molecules. ProFECT is the brand for T&T's lipid, polymer, and hybrid nanoparticle formulations.
Technologies
T&T Scientific is constantly innovating in the space of nanomedicine manufacturing and formulations. T&T has expanded its manufacturing technology to highly scalable, precise, low cost, and small footprint solvent injection technologies, NanoSizer Flow, starting with patent-approved continuous extrusion technology. The solvent injection technology is being widely used in COVID vaccines and other gene therapy manufacturing applications. Moreover, the formulation department at T&T develops novel Lipid Nanoparticle (LNP) formulations for a wide variety of active pharmaceutical ingredients (APIs), including mRNA, Self Amplifying RNA, Proteins, Antibodies, Peptides, siRNA, DNA, Small and Large Molecules. ProFECT is the brand for T&T's lipid, polymer, and hybrid nanoparticle formulations.
T&T Scientific Patented Technologies
NanoSizer MINI
NanoSizer MINI is the world’s first fully assembled lipid, liposome, and liquid polymer and nanoparticle extruder allowing researchers to save time and money, and avoid any chance of batch to batch contaminations which could save valuable laboratory and pharmaceutical solutions. Faster, cleaner, and easier extrusion and sizing every single time. NanoSizer MINI not only allows for performing research with highest level of confidence of cleanliness, it will also save tremendous amount of time and money to maximize the efficiency of the work. No assembly, cleaning or contamination.
NanoSizer MINI Sterile
NanoSizer MINI and PLUS Sterile are the world’s first disposable sterilized and fully assembled lipid/liposome extruder for sizing liposome, and liquid polymer and nanoparticle allowing researchers to save time and money, and avoid any chance of batch to batch contamination and growing bacteria which can save you precious laboratory and pharmaceutical solutions. Faster, cleaner, and easier extrusion every single time. Great for cell-included sizing research and sterilized liposome production. No need for autoclaving. Ethylene Oxide (EtO) sterilization process is perfoemed for sterilizing the extruder.
NanoSizer AUTO (1 | 10 | Plus | Ultra)
NanoSizer AUTO is transforming fully sterile liposome production of small and large volumes of solution alike, simplifying scale-up from the research labs to pharmaceutical manufacturing. This technology allows to extrude liposomes by pressing a button whether is 1 mL or 300 L with no need of assembling or cleaning. The fact that the temperature, flow rate, pressure, and number of passes are completely controlled makes the results consistent and repeatable which is a great factor in research, development and production of these nanoparticles.
Proprietary Note
Technologies in this website, as well as applications and methods and use, is covered by one or more U.S. or foreign patents or patents pending.
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